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Psychedelics for Anxiety, Depression, and PTSD, Part 2

File:FerndalePoliceStop102415.jpg

Drug paraphernalia including marijuana/cannabis and a methamphetamine pipe, following a police stop in Ferndale, CA, Author Ferndale Police Dept., Source https://kymkemp.com
(PD per California Public Records Act)

We continue our discussion of the risks and benefits of a drug-based psychiatric approach utilizing psychedelics to treat anxiety, depression, and post-traumatic stress disorder (PTSD).

Despite growing enthusiasm for the use of psychedelics, the evidence is far from in.

LSD

Lysergic acid diethylamide (LSD) – one of the most potent hallucinogens – was studied from the 1950s to 1970s in order to assess behavioral and personality changes, as well as relief from psychiatric symptoms [1][2A].

LSD was originally used in the treatment of anxiety, depression, addiction, and psychosomatic illness.  Readers may recall that the US Army and CIA, also, experimented with LSD as a truth serum.  But most early studies were not performed to today’s standards.

Across 11 randomized-controlled studies (involving a combined total of 567 patients) positive outcomes were observed, particularly with regard to alcoholism [2B].

In rare instances, however, psychedelics such as psilocybin and LSD can evoke a lasting psychotic reaction (more frequently in patients with a family history of psychosis) [3A].  Adequate screening of a patient’s vulnerability and prior psychotic episodes before the use of LSD is, therefore, emphasized. Continue reading

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